Localisation of experimental staphylococcal abscesses by 99MTC-technetium-labelled liposomes

Publisher Website
Google Scholar
Abstract
The accumulation of 99mTc-labeled liposomes in abscesses was studied. Abscesses were produced in the thighs of albino rats by i.m. injection of Staphylococcus aureus. After 4 days these abscesses were used to determine the localization of 99mTc-labeled anionic, cationic and neutral liposomes in the abscess area. This was achieved by radionuclide images produced by a gamma camera and an associated data-processing system. There was a pronounced uptake of 99mTc-labeled anionic liposomes in the abscess area compared with the corresponding unaffected thigh. Similar uptake was not shown by the 99mTc-labeled cationic and neutral liposomes. Abscess uptake of anionic liposomes was maximal at or before 30 min after injection and was not enhanced by prior opsonization with aggregated rat Ig.