Ca2+‐independent regulation of neurosecretion by intracellular Na+
- 4 November 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 292 (1-2) , 37-41
- https://doi.org/10.1016/0014-5793(91)80828-q
Abstract
While secretion from nerve endings is strictly controlled by an increase in cytoplasmic free calcium several reports suggest intracellular sodium may serve a regulatory role. Whether sodium acts directly to modulate secretion or indirectly by influencing cytoplasmic calcium dynamics is unknown. This study shows, based on parallel experiments studying [Na + ] i , [Ca 2+ ] i and vasopressin secretion, that sodium acts directly to regulate secretion in isolated nerve endings from the rat neurohypophysis. The elevation in secretion that develops is dose-dependently related to the [Na + ] i and can occur in the absence of changes in [Ca 2+ ] i .Keywords
This publication has 35 references indexed in Scilit:
- Technical Editors and ReviewersNuclear Engineering and Design, 1991
- Isolated neurosecretory nerve endings as a tool for studying the mechanism of stimulus-secretion couplingBioscience Reports, 1987
- Differential effect of intraterminal sodium on spontaneous quantal release of transmitter in two neuromuscular junctions of crayfishNeuroscience Letters, 1987
- The effect of sodium ions on MEPP frequency at the frog neuromuscular junctionLife Sciences, 1977
- Synaptic Facilitation: Long-Term Neuromuscular Facilitation in CrustaceansScience, 1971
- A Management-Responsibility Continuum.Academy of Management Proceedings, 1969
- Role of Sodium Ions in the Response of the Frequency of Miniature End-plate Potentials to Osmotic Changes in the Neuromuscular JunctionNature, 1969
- The influence of internal sodium on the behaviour of motor nerve endingsProceedings of the Royal Society of London. B. Biological Sciences, 1968
- The action of sodium pump inhibitors on neuromuscular transmissionProceedings of the Royal Society of London. B. Biological Sciences, 1968
- Influence of Sodium Ions on Transmitter ReleaseNature, 1965