Antipyrine clearance during experimental and occupational exposure to toluene.

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Abstract
Exposure to toluene vapor enhances hepatic microsomal enzyme function in animals as assessed by the metabolism of the test drug antipyrine. Printing trade workers (36) with long-term occupational exposure to a mixture of organic solvents and 39 matched controls were randomly allocated into 4 groups. Printers (18) and 21 controls were exposed to 100 ppm toluene during 6.5 h in an exposure chamber. The remaining 18 printers and 18 controls were exposed to 0 ppm toluene under similar conditions. The salivary clearance of antipyrine was measured immediately after the stay in the exposure chamber to investigate a possible acute change in liver function and was repeated 2 wk later, shortly before the summer vacation. Antipyrine clearance was measured again at the end of the summer vacation, 4 wk after exposure. To study a possible effect of chronic exposure on antipyrine clearance 12 printing trade workers with 17 yr (median) occupational exposure to toluene vapor at concentrations of .apprx. 100 ppm were investigated before and 4 wk after cessation of exposure. No difference in antipyrine clearance was found within the groups or between the groups at any measurement.

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