Molecular cloning and characterization of the rat NMDA receptor
- 7 November 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 354 (6348) , 31-37
- https://doi.org/10.1038/354031a0
Abstract
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.Keywords
This publication has 43 references indexed in Scilit:
- Pharmacological and functional characteristics of metabotropic excitatory amino acid receptorsTrends in Pharmacological Sciences, 1990
- A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel propertiesNeuron, 1990
- Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualateFEBS Letters, 1990
- Excitatory amino acid neurotoxicity and neurodegenerative diseaseTrends in Pharmacological Sciences, 1990
- Molecular Cloning and Functional Expression of Glutamate Receptor Subunit GenesScience, 1990
- A Family of AMPA-Selective Glutamate ReceptorsScience, 1990
- Excitatory amino acid receptors and synaptic plasticityTrends in Pharmacological Sciences, 1990
- Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonistsTrends in Pharmacological Sciences, 1990
- Cloning by functional expression of a member of the glutamate receptor familyNature, 1989
- The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous SystemAnnual Review of Pharmacology and Toxicology, 1989