ANTI‐AGGREGATORY EFFECT OF PROSTACYCLIN (PGI2) in vivo
Open Access
- 1 May 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 66 (1) , 10-12
- https://doi.org/10.1111/j.1476-5381.1979.tb16090.x
Abstract
Prostacyclin (PGI2) when infused intravenously reduced the mortality of rabbits given high intravenous doses of arachidonic acid (AA). Prostaglandins E1 and D2 were ineffective. Indomethacin pretreatment abolished the toxic AA effect. Since the lethal effect of AA is partly due to the formation of platelet aggregates it is concluded that PGI2 is a most potent antiaggregatory prostaglandin in vivo.Keywords
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