Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis
- 1 December 1992
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 55 (12) , 1732-1740
- https://doi.org/10.1021/np50090a003
Abstract
The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.Keywords
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