Vibrational Study of a Nucleoside Analogue with Antitumoral and Antiviral Activity, 5-Fluoro-2′-deoxyuridine, FdU
- 1 July 1997
- journal article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (7) , 1041-1044
- https://doi.org/10.1080/07328319708006128
Abstract
The advantages of different methods for obtaining a reliable assignment of the vibrational spectra of the antitumoral and antiviral nucleoside analogue, 5-fluoro-2′-deoxyuridine. FdU, are evaluated as a basis for the study of FdU-containing polymers and drug-target interactions. The experimental FT-IR and FT-Raman spectra, are compared with theoretical frequencies obtained by a classical mechanics method and a semiempirical molecular orbital (MO) method, PM3.Keywords
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