Activity of Ketoconazole and Its Deacyl Derivative Against Plasmodium falciparum and Candida Isolates

Abstract
Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [ 3 H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.