Serological and histological characterization of the new mutant strain of lpr mice, CBA/KUms-lprcg/lprcg

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Abstract
CBA/KIJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation wereinvestigated for their serological and histological characteristics. The mutant mice showed elevatedlevels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigenssuch as dsDNA and ssDNA and poly(ADP-ribose). In contrast, histopathological lesions, e.g.glomerulonephritis, vasculitis or interstitial pneumonitis, were not revealed by histological andimmunofluorescent examinations, except for lymphocytic infiltration in various organs. These resultssuggest that this mutant mouse strain may provide a new animal model For autoimmunity. However, further investigations are required to clarify whether this strain is unique as compared with otherwell-known lupus-prone strains of mice with respect to serological and histological abnormalities andbecome to be a new model of systemic autoimmune disease.