Fetuin-A and Incident Diabetes Mellitus in Older Persons
- 9 July 2008
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 300 (2) , 182-8
- https://doi.org/10.1001/jama.300.2.182
Abstract
Fetuin-A is a hepatic secretory protein that binds the insulin receptor and inhibits insulin action in vitro. In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown. To determine whether fetuin-A levels are associated with incident diabetes in older persons. Observational study among 3075 well-functioning persons aged 70 to 79 years. In this case-cohort study, we retrospectively measured fetuin-A levels in baseline serum among 406 randomly selected participants without prevalent diabetes, and all participants who developed incident diabetes mellitus during a 6-year follow-up (to August 31, 2005). Incident diabetes mellitus. Incident diabetes developed in 135 participants (10.1 cases/1000 person-years). Participants with fetuin-A levels within the highest tertile (> 0.97 g/L) had an increased risk of incident diabetes (13.3 cases/1000 person-years) compared with participants in the lowest tertile (< or = 0.76 g/L) (6.5 cases/1000 person-years) in models adjusted for age, sex, race, waist circumference, body weight, physical activity, blood pressure level, fasting glucose level, high-density lipoprotein cholesterol concentration, triglyceride concentration, and C-reactive protein level (adjusted hazard ratio, 2.41; 95% confidence interval, 1.28-4.53; P = .007). The association was not affected by adipocytokine levels but was moderately attenuated by adjustment for visceral adiposity (adjusted hazard ratio of highest vs lowest tertile 1.72; 95% confidence interval, 0.98-3.05; P = .06). Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance.Keywords
This publication has 42 references indexed in Scilit:
- Fetuin-A is not associated with mortality in chronic kidney diseaseKidney International, 2007
- Fetuin-A Is an Independent Predictor of Death after ST-Elevation Myocardial InfarctionClinical Chemistry, 2007
- Association of serum fetuin-A levels with mortality in dialysis patientsKidney International, 2007
- Association of Fetuin-A With Mitral Annular Calcification and Aortic Stenosis Among Persons With Coronary Heart DiseaseCirculation, 2007
- Fetuin-null mice are protected against obesity and insulin resistance associated with agingPublished by Elsevier ,2006
- Fetuin-A and kidney function in persons with coronary artery disease—data from the heart and soul studyNephrology Dialysis Transplantation, 2006
- Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuinKidney International, 2005
- Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patientsNephrology Dialysis Transplantation, 2005
- Diabetes in older adults: comparison of 1997 American Diabetes Association classification of diabetes mellitus with 1985 WHO classificationThe Lancet, 1998
- Bovine fetuin is an inhibitor of insulin receptor tyrosine kinaseLife Sciences, 1997