Studies on the mechanism of action of the histone kinase dependent on adenosine 3′,5′‐monophosphate
- 1 October 1983
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 135 (3) , 491-495
- https://doi.org/10.1111/j.1432-1033.1983.tb07678.x
Abstract
The transient phase of histone H1 phosphorylation was studied by the quenched-flow method. A minimal kinetic scheme of the above process was proposed. A formal kinetic analysis was given to a 4-step mechanism of the reaction. Computer stimulation of the transient-phase kinetics of H1 phosphorylation and the steady-state kinetics of phosphate transfer from the enzyme phosphoform to histone permitted an estimate of all kinetic constants of the proposed mechanism.This publication has 20 references indexed in Scilit:
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