An analysis of the role of calcium in facilitation at the frog neuromuscular junction

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Abstract
1. Under appropriate conditions stimulation of the neuromuscular junction by a single impulse or a brief train causes subsequent impulses to release increased amounts of transmitter. It has been proposed that this facilitation of transmitter release is due to calcium which remains on release sites following the conditioning stimuli. This residual calcium hypothesis is examined in frog cutaneous pectoris muscle in the present study.