Antagonism of the Hemorrhagic Syndrome Induced by Derivatives of 3-Hydroxy-l, 4-Naphthoquinone.

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Abstract
The development of hypoprothrombinemia and hemorrhagic lesions which occurred in the albino rat as the result of ingestion of 2-cyclo-hexyl-3-hydroxy-l,4-naphthoquinone (SN 5094), 2-(2-meth-yloctyI)-3-hydroxy-l,4-naphthoquinone (SN 5949), and 2[3-(p-phenoxyphenyl)propyl]-3- hydroxy- 1,4- naphthoqui-none (SN 13,936), could be prevented either partially or completely by simultaneous admn. of 2-methyl-l,4-naphtho-quinone or vit. K1. In each instance vit. K1 proved more effective than 2-methyl-l,4-naphthoquinone. These findings confirm the author''s previous suggestion that the hemorrhagic syndrome, which results from the admn. of 2-sub-stituted-3-hydroxy-1,4-naphthoquinones, is due to competition between these substances and the K vits. in processes involved in prothrombin formation.

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