Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release
Open Access
- 24 April 2009
- journal article
- Published by Springer Nature in BMC Biochemistry
- Vol. 10 (1) , 12
- https://doi.org/10.1186/1471-2091-10-12
Abstract
The ALG2-interacting protein X (ALIX)/AIP1 is an adaptor protein with multiple functions in intracellular protein trafficking that plays a central role in the biogenesis of enveloped viruses. The ubiquitin E3-ligase POSH (plenty of SH3) augments HIV-1 egress by facilitating the transport of Gag to the cell membrane. Recently, it was reported, that POSH interacts with ALIX and thereby enhances ALIX mediated phenotypes in Drosophila.Keywords
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