Influence of diethylmaleate on the formation of bis(methylmercuric)selenide and methylmercury distribution in rats.
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 6 (12) , 950-953
- https://doi.org/10.1248/bpb1978.6.950
Abstract
The role of bis (methylmercuric) selenide (BMS) in selenite-induced redistribution of methylmercury was studied in rats. Pretreatment of diethylmaleate (DEM), which depletes tissue reduced glutathione (GSH), completely suppressed the significant increase of BMS produced by selenite injection in the blood of methylmercury-treated rats. Its inhibitory effect was also observed in the kidney and brain. Under the same conditions, the characteristic accumulation in the brain and testis of total Hg induced by selenite was markedly inhibited by DEM pretreatment. Total Hg in these tissues was not altered by DEM alone and BMS in the blood existed in the erythrocytes, but not in the plasma. Apparently, the suppressed formation of BMS in the erythrocytes leads mainly to the decreased accumulation of total Hg in the brain and testis.This publication has 1 reference indexed in Scilit:
- Formation and possible role of bis(methylmercuric) selenide in rats treated with methylmercury and seleniteBiochemical Pharmacology, 1982