Langerhans Cells in Contact Dermatitis of the Guinea Pig
- 1 September 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 114 (9) , 1309-1313
- https://doi.org/10.1001/archderm.114.9.1309
Abstract
In the guinea pig, the epidermal Langerhans cells studied by ATPase and EM techniques in dinitrochlorobenzene-induced contact dermatitis showed early cellular vacuolar and granular changes and intraepidermal contact with mononuclear cells. At later periods of up to 48 h, the Langerhans cells migrated to the surface of a thickened epidermis and were lost in the parakeratotic horny layer that was shed. The Langerhans cell probably has a macrophage-type role in the epidermal reaction of contact dermatitis, and as the spongiosis and the inflammatory reaction develop, theses cells are shed with the degenerating keratinocytes.This publication has 4 references indexed in Scilit:
- Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodesCellular Immunology, 1976
- The role of langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigsJournal of Investigative Dermatology, 1976
- The Disappearance and Regeneration of Langerhans Cells following Epidermal Injury**From the Mayo Clinic and Mayo Foundation: Section of Dermatology and the Mayo Graduate School of Medicine (University of Minnesota), Rochester.Journal of Investigative Dermatology, 1968
- An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England.Journal of Investigative Dermatology, 1961