Antisense Nucleic Acids — Prospects for Antiviral Intervention
- 1 August 1993
- journal article
- Published by SAGE Publications in Antiviral Chemistry and Chemotherapy
- Vol. 4 (4) , 193-200
- https://doi.org/10.1177/095632029300400401
Abstract
Antisense oligodeoxynucleotides are a promising new class of antiviral agent. Because they bind in a sequence-specific manner to complementary regions of mRNA, oligos can inhibit gene expression in a sequence-specific manner. The ‘antisense’ approach has been used successfully to block cellular expression and replication of several viruses including Human Immunodeficiency Virus-1 (HIV-1), and Herpes Simplex Virus (HSV). However, the antiviral effect of oligodeoxynucleotides is not limited to sequence-specific inhibition of gene expression. Non sequence-specific effects are frequently observed, presumably as a result of their properties as polyanions. Occasionally (e.g. for HIV-1) these non sequence-specific effects are also therapeutic. The prospects for antisense oligodeoxynucleotide therapy for viral disease are discussed.Keywords
This publication has 37 references indexed in Scilit:
- Sulfated Polyester Interactions with the CD4 Molecule and with the Third Variable Loop Domain (v3) of gp120 Are Chemically DistinctAIDS Research and Human Retroviruses, 1992
- Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?Pharmacology & Therapeutics, 1991
- Differential Alteration of the Anti-HIV-1 Effect of Phosphorothioate Oligonucleotide S-dC28 by AZT, Interferon-Alpha, and Dextran SulfateAIDS Research and Human Retroviruses, 1991
- Antisense Oligodeoxyribonucleotides Inhibit the Expression of the Gene for Hepatitis B Virus Surface AntigenJournal of General Virology, 1990
- Complementary oligonucleotide sequence inhibits both Vmw65 gene expression and replication of herpes simplex virusAntiviral Research, 1990
- A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus‐specific proteins in MDCK cellsFEBS Letters, 1990
- Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cellsFEBS Letters, 1989
- Human immunodeficiency virus induces phosphorylation of its cell surface receptorNature, 1988
- Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonatesBiochemistry, 1986
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973