Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae
- 6 April 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 214 (1) , 158-162
- https://doi.org/10.1016/0014-5793(87)80033-9
Abstract
The ability of purified mitochondria isolated from S. cerevisiae to synthesize fatty acids and especially very long chain fatty acids (VLCFA) has been investigated. The VLCFA synthesis requires malonyl‐CoA as the C2 unit donor and NADPH as the reducing agent. Moreover the yeast mitochondrial elongase is able to accept either exogenous long chain fatty acyl‐CoAs as substrates or elongate endogenous substrates. In the latter case, ATP is required for full activity. Besides this important VLCFA formation, the mitochondria from S. cerevisiae were also able to synthesize C16 and C18.Keywords
This publication has 18 references indexed in Scilit:
- Fatty acid synthesis in mitochondria of Euglena gracilisEuropean Journal of Biochemistry, 1984
- Biosynthesis of very long chain fatty acids in microsomes from epidermal cells of Allium porrum LArchives of Biochemistry and Biophysics, 1984
- Comparative analysis of excreta and fat body from various cockroach speciesComparative Biochemistry and Physiology Part A: Physiology, 1979
- Lignoceric Acid Biosynthesis in the Developing Brain. Activities of Mitochondria1 Acetyl‐CoA‐Dependent Synthesis and Microsomal Malonyl‐CoA Chain‐Elongating System in Relation to MyelinationEuropean Journal of Biochemistry, 1977
- Elongation of palmityl-CoA in mouse brain mitochondria. Comparison with stearyl-CoABiochemical and Biophysical Research Communications, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Biosynthèse des acides gras dans les mitochondries de cerveau de souris en présence de malonyl-CoA ou d'acétyl-CoABiochimie, 1976
- Biosynthèse des acides gras dans les mitochondries végétales isoléesEuropean Journal of Biochemistry, 1972
- In vitro synthesis of lignoceric and nervonic acids in mammalian liver and brainBiochemistry, 1970
- Fatty acid synthesis by chain elongation in rat-liver mitochondriaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968