Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination
- 1 February 2009
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 191 (3) , 1115-1117
- https://doi.org/10.1128/jb.01260-08
Abstract
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.Keywords
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