Determination of Serum Proteins and Polysaccharides
- 1 May 1955
- journal article
- other
- Published by American Medical Association (AMA) in A.M.A. Archives of Neurology & Psychiatry
- Vol. 73 (5) , 536-543
- https://doi.org/10.1001/archneurpsyc.1955.02330110052007
Abstract
Tönnies,1in a review of the literature on the changes in the serum proteins due to tumor growth, notes that a high globulin-to-albumin ratio has been found consistently in association with human cancer. This observation, based upon studies employing the older techniques of protein chemistry, has been confirmed by the newer method of electrophoresis of moving boundaries.2Janssen,3also using electrophoretic methods, found an increase in the gamma globulin content of the serum from patients with cancer in the pancreas or liver. Rundles and associates4found hypoalbuminemia and increases occurring in the various globulin fractions in patients who were seriously ill with chronic lymphocytic leukemia, with chronic granulocytic leukemia, or with acute or subacute leukemia. More recently, paper electrophoresis has been used for the analysis of serum proteins.* Knedel and Zettel8applied the method to cases of bronchial carcinoma and found a significant increase inKeywords
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