Effect of Small Doses of Cortisone upon Urinary 17-Ketosteroid Fractions in Patients with Ovarian Dysfunction

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Abstract
A study was made of the effects of cortisone or hydrocortisone in a dosage of 5 mg either every 8 hours or four times daily upon the 17-ketosteroid fractions in the urine of 10 women with varying degrees of ovarian dysfunction and 1 normal subject. The patterns of excretion of dehydroepiandrosterone, androsterone and etiocholanolone before treatment varied considerably between different subjects, but were remarkably constant for each individual. Regardless of the pretreatment pattern, treatment resulted in significant decreases in all 3 fractions to a fairly constant pattern similar to that for the normal subject of this study and to the average pattern for normal women. Although these observations tend to favor the adrenal cortex as the primary site of a disorder of steroid metabolism in these patients, the existence of disorders of steroid metabolism in the ovary or liver as causes of similar clinical pictures cannot be excluded.

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