Binding of Drugs to Serum Albumin

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Abstract
Most drugs are carried from their sites of absorption to their sites of action and elimination by the circulating blood. Some drugs are simply dissolved in serum water, but many others are partly associated with blood constituents such as albumin, globulins, lipoproteins and erythrocytes. For the great majority of drugs binding to serum albumin is quantitatively by far the most important and often accounts for almost the entire drug binding in plasma.1 2 3 Albumin binding influences the fate of drugs in the body. Only the unbound or free drug diffuses through capillary walls, reaches the site of drug action, and is . . .

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