Mycophenolate mofetil in animal models of autoimmune disease
- 1 March 2005
- journal article
- review article
- Published by SAGE Publications in Lupus
- Vol. 14 (3_suppl) , 12-16
- https://doi.org/10.1191/0961203305lu2112oa
Abstract
Mycofenolate mofetil (MMF-Cellcept) is an immunomodulatory drug utilized extensively in transplant medicine. The efficacy of regimes including Cellcept in preventing allograft rejection, and in the treatment of rejection, is now firmly established. The immunosuppressive actions of this drug enabled the investigation for the beneficial effects in autoimmune diseases. We review the evidence for the contribution of MMF in autoimmunity in animal models of systemic lupus erythematosus (SLE), mercury induced autoimmune glomerulonephritis, diabetes mellitus, experimental autoimmune uveoretinitis, and experimental allergic encephalitis. MMF has an influence on the T and B cell pathways. It is immunosuppressive and anti-inflammatory.Keywords
This publication has 16 references indexed in Scilit:
- Antidiabetogenic effect of mycophenolate mofetil is associated with down-regulation of adhesive interactions and autoreactive cell activation.Annals of the New York Academy of Sciences, 2006
- Modulation of autoantibody production by mycophenolate mofetil: effects on the development of SLE in (NZBxNZW)F1 miceNephrology Dialysis Transplantation, 2003
- Effect of mycophenolate mofetil on severity of nephritis and nitric oxide production in lupus-prone MRL/lpr miceLupus, 2002
- Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitisInternational Immunopharmacology, 2001
- Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritisKidney International, 2001
- Mycophenolate mofetil reduces renal cortical inducible nitric oxide synthase mRNA expression and diminishes glomerulosclerosis in MRL/lpr miceJournal of Laboratory and Clinical Medicine, 2001
- Inosine monophosphate dehydrogenase (IMPDH) inhibitionin vitrosuppresses lymphocyte proliferation and the production of immunoglobulins, autoantibodies and cytokines in splenocytes from MRLlpr/lprmiceClinical and Experimental Immunology, 2001
- Mycophenolate Mofetil Ameliorates Perivascular T Lymphocyte Inflammation and Reduces the Double-Negative T Cell Population in SLE-Prone MRLlpr/lpr MiceCellular Immunology, 1999
- Beneficial effect of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil on survival and severity of glomerulonephritis in systemic lupus erythematosus (SLE)-prone MRLlpr/lprmiceClinical and Experimental Immunology, 1999
- Inhibition of experimental autoimmune uveoretinitis by mycophenolate mofetil, an inhibitor of purine metabolismExperimental Eye Research, 1995