Persistently elevated AFP and AChE in amniotic fluid from a normal fetus following demise of its twin

1 January 1986

journal article
research article
Published by Wiley in Prenatal Diagnosis

Vol. 6 (1) , 33-35
https://doi.org/10.1002/pd.1970060105

Abstract

Intrauterine fetal demise (IUFD) in one of twins at 12 weeks of gestation was accompanied by markedly elevated maternal serum alpha‐fetoprotein (AFP) at 17 and 18 weeks. Amniotic fluid AFP from the healthy surviving twin's sac at 18·5 and 23 weeks was also greatly increased along with a positive acetylcholinesterase (AChE) band. Persistently elevated AFP and positive AChE so long after fetal demise–‐6·5 and 11 weeks post IUFD–‐has not, to our knowledge, been previously described. In similar cases, high level ultrasound and careful placental examination at birth should be utilized to search for fetal abnormalities or multiple pregnancy with IUFD.

Keywords

This publication has 2 references indexed in Scilit:

Amniotic band disruption syndrome associated with elevated amniotic AFP and normal acetylcholinesterase gel test
Prenatal Diagnosis, 1984
Predictive value of amniotic acetylcholinesterase analysis in the diagnosis of fetal abnormality in 3700 pregnancies
Prenatal Diagnosis, 1984