INHIBITION BY RELAXIN OF SPONTANEOUS CONTRACTIONS OF THE UTERUS OF THE HAMSTER IN VITRO

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Abstract
Since the discovery that relaxin-containing preparations of the ovary of the sow inhibit uterine contractions in the non-pregnant rat, mouse and guinea-pig in vivo (Krantz, Bryant & Carr, 1950) and in vitro (Sawyer, Frieden & Martin, 1953) this property of relaxin has been tested in only a few species, and the results reported are confusing. Miller & Murray (1959), for example, failed to get inhibition of the human or rabbit uterus in vitro. In the rat, mouse and guinea-pig relaxin decreases the amplitude of contractions in the oestrogen-dominated uterus. However, in the progesterone-dominated uterus, relaxin decreases tone but has only slight and inconsistent effects on amplitude. There have been no reports of the action of relaxin on the uterus of the hamster. In this study, forty adult female hamsters from an accredited breeder were used. Twenty-two were parous animals of which three were killed during natural oestrus and 19 were

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