Effects of PGE2 and PGF2α on the simulation by noradrenaline and oxytocin of human cervical muscle activity at term

Abstract
Cervical specimens were obtained by needle biopsy in connection with caesarean section at term pregnancy. The preparations were superfused in an organ chamber and contractions were registered isometrically. Prostaglandin (PG) E2 and F inhibited spontaneous contractions. The stimulatory action of noradrenaline was not influenced by PGF but was reduced by PGE2 whereas both PGs abolished the excitatory effect of oxytocin.