Turnover of 5-Hydroxytryptamine (Serotonin) in Tissues.

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Abstract
Use of tryptophan-C14 and 5-hydroxytryptophan-C14 made it possible to measure turnover of serotonin in a number of tissues in the rabbit. The measured half-lives were: platelets and spleen, 33-48 hours; stomach, 17 hours; intestine, 11 hours. Although amounts in the brain were too small to permit isotopic measurement, estimates from the increase following administration of harmaline (3,4-dihydroharmine), an inhibitor of serotonin metabolism, indicated a half-life in brain of the order of minutes.