Selective uptake of75Se-selenomethionine by thymoma with pure red cell aplasia

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Abstract
Red blood aplasia and an enlarging anterior mediastinal mass developed in a patient being followed for thyroid carcinoma. Differential diagnosis included thymoma and metastatic thyroid carcinoma. Preoperative scanning demonstrated significant uptake of 75Se-selenomethionine; 67Ga-gallium citrate failed to visualize the mass. Subsequent thoracotomy revealed a lymphocytic thymoma which was resected, resulting in reversal of red cell aplasia. The use of 75Se-selenomethionine scanning may be a useful adjunct in the preoperative evaluation of suspected thymomas.