Enhanced killing of hypoxic tumour cells by hyperthermia

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Abstract
There is abundant evidence that cancer cells grown in vivo or in vitro are sensitive to elevated temperature (Cavaliere, 1967; Overgaard and Overgaard, 1972). Clinically, Coley (1893), near the beginning of this century, achieved a considerable success in the regression of tumours by inducing high temperatures in cancer patients with bacterial toxins. Since then, the literature contains numerous cases of the arrest or total disappearance of cancer after prolonged fever (Cavaliere, 1967). Recently, renewed interest in the combined use of hyperthermia and radiotherapy or chemotherapy has been generated at both the laboratory and the clinical level (Suit and Shwayder, 1974).