Novel Mutations in ndh in Isoniazid-Resistant Mycobacterium tuberculosis Isolates
Open Access
- 1 July 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (7) , 2157-2159
- https://doi.org/10.1128/aac.45.7.2157-2159.2001
Abstract
Novel mutations in NADH dehydrogenase (ndh) were detected in 8 of 84 (9.5%) isoniazid (INH)-resistant isolates (T110A [n = 1], R268H [n = 7]), but not in 22 INH-susceptible isolates of Mycobacterium tuberculosis. Significantly, all eight isolates with mutations atndh did not have mutations at katG, kasA, or the promoter regions of inhA or ahpC, except for one isolate. Mutations in ndh appear to be an additional molecular mechanism for isoniazid resistance in M. tuberculosis.Keywords
This publication has 26 references indexed in Scilit:
- High-resolution minisatellite-based typing as a portable approach to global analysis ofMycobacterium tuberculosismolecular epidemiologyProceedings of the National Academy of Sciences, 2001
- Variable human minisatellite‐like regions in the Mycobacterium tuberculosis genomeMolecular Microbiology, 2000
- Inhibition of a Mycobacterium tuberculosis β-Ketoacyl ACP Synthase by IsoniazidScience, 1998
- Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosisScience, 1998
- Characterization of the Catalase-Peroxidase Gene (katG) and inhA Locus in Isoniazid-Resistant and -Susceptible Strains of Mycobacterium tuberculosis by Automated DNA Sequencing: Restricted Array of Mutations Associated with Drug ResistanceThe Journal of Infectious Diseases, 1996
- Flavin-Dependent Alkyl Hydroperoxide Reductase from Salmonella typhimurium. 1. Purification and Enzymatic Activities of Overexpressed AhpF and AhpC ProteinsBiochemistry, 1996
- Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 1995
- Purification and Characterization of the Mycobacterium smegmatis Catalase-Peroxidase Involved in Isoniazid ActivationPublished by Elsevier ,1995
- Enzymic Characterization of the Target for Isoniazid in Mycobacterium tuberculosisBiochemistry, 1995
- Missense mutations in the catalase‐peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosisMolecular Microbiology, 1995