Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method

Abstract
Catecholamines and indolealkylamines are of clinical interest in neurological and psychiatric disorders. 3-Methoxy-dopa, 3-methoxy-4-hydroxyphenylglycol, dihydroxyphenylacetic acid, tryptophan, 5-hydroyIAA [HIAA] and homovanillic acid [HVA] levels were measured in human CSF with a simple, sensitive, inexpensive, rapid and accurate procedure using high performance liquid chromatography coupled to an electrochemical detector. Patients with Parkinson''s disease have a decrement in HVA that is reversed by treatment with L-dopa. After this medication, 3-methoxy-dopa is measurable in CSF. Patients with depression show a decrease in serotonin [5-hydroxytryptamine] turnover expressed by diminished 5-HIAA content in CSF. Depressed patients also show low levels of tryptophan. Monoamine metabolites are augmented in patients with subarachnoid hemorrhage.

This publication has 12 references indexed in Scilit: