LYMPHOCYTOXIC ANTIBODY RESPONSES TO TRANSFUSIONS IN POTENTIAL KIDNEY TRANSPLANT RECIPIENTS

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Abstract
A series of 737 hemodialysis patients were studied for the relationship between lymphocytotoxic antibody formation and blood transfusions; 331 thereof were studied prospectively. With up to 20 transfusions, highly reactive (> 90% reactivity against random panel) antibodies were not found in any of the prospectively studied males or females without previous pregnancies. Nearly 90% of the males failed to form antibodies against > 10% of the panel donors. Patients with previous pregnancies developed antibodies at a much higher rate. Among 316 patients tested, antibodies against B cells were found more frequently than antibodies against T cells. T and B cell antibody levels often decreased in spite of additional transfusions. The risk of rendering a patient untransplantable because of sensitization as a result of transfusions apparently is very small.

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