Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

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Abstract
Breast cancer is the most common invasive cancer in US women and its etiology is not fully defined.1,2 Despite observational studies suggesting increased breast cancer risk with estrogen3 and especially long-duration combined hormone use,4,5 the magnitude of breast cancer risk associated with menopausal hormone therapy is controversial.6,7

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