Adipose compartmentalization and insulin resistance among obese HIV-infected women: the role of intermuscular adipose tissue
Open Access
- 1 July 2007
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 86 (1) , 5-6
- https://doi.org/10.1093/ajcn/86.1.5
Abstract
Changes in adipose tissue volume and distribution have been linked to the development of insulin resistance and the metabolic syndrome in non-HIV-infected individuals. These changes may occur in conjunction with obesity or disorders of altered body fat distribution, often termed lipodystrophy. Indeed, the distribution of adipose tissue is an important determinant of metabolic risk, including insulin resistance. In this regard, both increases in visceral adipose tissue (VAT) and decreases in subcutaneous adipose tissue (SAT) are independently associated with metabolic abnormalities and increased insulin resistance in non-HIV-infected adults (1).Keywords
This publication has 11 references indexed in Scilit:
- Independent associations of insulin resistance with high whole-body intermuscular and low leg subcutaneous adipose tissue distribution in obese HIV-infected womenThe American Journal of Clinical Nutrition, 2007
- Improved Triglycerides and Insulin Sensitivity with 3 Months of Acipimox in Human Immunodeficiency Virus-infected Patients with HypertriglyceridemiaJournal of Clinical Endocrinology & Metabolism, 2006
- Metabolic and Skeletal Complications of HIV InfectionJAMA, 2006
- Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic womenThe American Journal of Clinical Nutrition, 2005
- Differential Effects of Metformin and Exercise on Muscle Adiposity and Metabolic Indices in Human Immunodeficiency Virus-Infected PatientsJournal of Clinical Endocrinology & Metabolism, 2004
- Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of ‘systemic steatosis’Current Opinion in Lipidology, 2004
- Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndromeJournal of Applied Physiology, 2003
- Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related LipodystrophyDiabetes, 2002
- Increased rates of lipolysis among human immunodeficiency virus[ndash ]infected men receiving highly active antiretroviral therapyMetabolism, 2002
- Association of Severe Insulin Resistance With Both Loss of Limb Fat and Elevated Serum Tumor Necrosis Factor Receptor Levels in HIV LipodystrophyJAIDS Journal of Acquired Immune Deficiency Syndromes, 2000