Descriptions of a limited number of instances of congenital defect of the skin of the new-born are to be found in the literature. Most of these have appeared in publications devoted to pediatrics. It is of interest to note a case first recognized when the patient was in his thirty-eighth year. Congenital defect of the skin of the new-born is an extraordinary condition, characterized by absence at birth of circumscribed areas of integument. The defect is usually solitary, but lesions may be multiple, in which case they are usually either grouped or symmetrically located. The outline is sharply defined and circular or oval in most instances and from 1 to 5 or more cm. in diameter. The epidermis and dermis are absent, but the subcutaneous tissue is little affected, and there is no evidence of inflammation. The site of predilection is the vertex of the scalp, but cases have been