HLA class I alleles and cervical neoplasia.
Open Access
- 15 May 2003
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 187 (10) , 1675-1676
- https://doi.org/10.1086/374938
Abstract
To the Editor —In a recent issue of the Journal, Wang et al. show that women with the class I HLA-CW*0202 allele have a reduced risk for development of either cervical neoplasia or cervical carcinoma (CxCa) [1]. They found this relationship in 3 different study populations (1 from Portland, Oregon, 1 from the eastern United States, and 1 from Guanacaste, Costa Rica) and in different ethnic groups. In their study, the authors state that the HLA-A*0201 allele (the most common in the human population) is not associated with an increased or decreased risk for development of CxCa, but they do not show details of the distribution of the HLA-A*0201 allele among the patients with low-grade squamous epithelial lesions (LSILs), high-grade squamous epithelial lesions (HSILs), or cancerKeywords
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