Increased plasma pancreatic polypeptide (PP) in diabetic ketoacidosis; normalization following treatment

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Abstract
As both hypoglycemia and hyperglycemia may modify plasma levels pancreatic polypeptide (PP), we measured plasma PP by a homologous radioimmunoassay in 7 diabetics who were admitted to the hospital in overt diabetic ketoacidosis (initial blood glucose 27.1-55.0 mmol/l). None had circulating PP-antibodies. All were treated with continuous infusion of insulin and fluids. Before starting treatment, plasma PP ranged 2585-136 pmol/l (mean 629 pmol/l). Following treatment, plasma PP decreased gradually in all patients. The following morning, mean plasma PP was 242 pmol/l, 67 pmol/l when 1 uremic patient was excluded. The normal value is < 100 pmol/l. This study shows that plasma PP is clearly elevated in diabetic ketoacidosis and decreases following treatment.