Metabolism of Linoleic Acid in Relation to Dietary Monoenoic Fatty Acids in the Rat

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Abstract
To study the interaction of dietary monoenoic fatty acids with the metabolism of essential fatty acids, weanling rats were fed a fat-free diet supplemented with oleic and linoleic acids in several ratios. The fatty acid composition of liver lipids was determined by gas-liquid chromatography. The conversion of oleic to eicosatrienoic acid was inhibited by dietary linoleic acid at all dietary levels of oleic acid investigated. The metabolism of linoleic acid could be influenced only when extremely high ratios of oleic to linoleic acid were fed. Petroselinic and erucic acids, representing isomers and homologues of oleic acid, were also fed as possible inhibitors of the metabolism of linoleic acid. Petroselinic acid interfered with the metabolism of linoleic and oleic acids, whereas erucic acid had little effect.