The Effect of TRH, Cyproheptadine and Pimozide on the Growth Hormone Response to Intramuscular Glucagon

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Abstract
Glucagon-induced growth hormone (GH) secretion was studied in healthy subjects under basal conditions (18), and when treated with TRH (10), cyproheptadine (8) and pimozide (6). With glucagon alone, the mean serum GH level significantly increased at 150 and 180 min. TRH administered as a bolus injection completely suppressed the GH response to glucagon. Cyproheptadine pretreatment resulted in a substantial suppression of the GH response to glucagon. A significant difference between basal and post-cyproheptadine GH levels were observed at 150 min after glucagon. Pimozide pretreatment was followed by a reduction of GH response to glucagon, but the difference between control and pimozide-treated groups was not significant. Glucagon-induced GH secretion apparently is at least partly mediated via serotoninergic mechanisms while significant dopaminergic involvement does not seem probable. TRH apparently plays a substantial inhibitory role in glucagon-stimulated GH secretion.

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