Disposition of Furosemide and Diuretic Response in Man

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Abstract
Four doses (5, 10, 20, 40 mg) of furosemide were orally administered to 3 healthy male subjects. Urine samples were collected after predetermined time intervals and urinary excretions of the drug, Na+ and K+ were determined as well as urine volumes. Linear relationship was observed between increments of cumulative Na+ + K+ excretion and urine volumes. Durations of diuretic response were about 3 h regardless of the dose administered, thereafter, Na+ + K+ excretions and urine volumes were below control levels. Three-hour cumulations of urinary Na+ + K+ excretion increments were linearly related to logarithm of the amount of furosemide administered.

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