Efficient Total Synthesis of Khafrefungin: Convergent Approach Using Suzuki Coupling under Thallium-free Conditions Toward Multigram-scale Synthesis
- 1 March 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (04) , 0601-0603
- https://doi.org/10.1055/s-2002-22726
Abstract
An efficient and practical synthetic route to khafrefungin, an antifungal agent, has been developed based on successive coupling of three components, 3, 4, and then 2. A key step of the synthesis is the Suzuki coupling of 2 and 10, in which the use of toxic thallium ethoxide has been avoided, and the coupling adduct (11) was obtained in multigram-scale quantities.Keywords
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