Influence of Oligodeoxyribonucleotides on the Immune Response of Newborn AKR Mice.

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Abstract
Summary Oligodeoxyribonucleotides, administered to newborn AKR mice in conjunction with sheep red blood cells, influence the time of appearance of hemolysin-forming cells in pancreatic and mesenteric lymph nodes. Thus, in comparison with animals that received the antigen only, 5- and 7-day-old animals injected with antigen and oligodeoxyribonucleotides, subsequently showed hemolysin-forming lymph node cells one to 3 days earlier. Such differences were not detected in assays on spleen cell populations and circulating hemolysins. The sequence of first appearance of antibody-producing cells in the organs assayed was spleen→pancreatic lymph nodes→mesenteric lymph nodes, and this sequence was not affected by administration of oligodeoxyribonucleotides.

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