Effect of Insulin, Adrenal Cortical Hormones, Salt and dl-Alanine on Carbohydrate Metabolism in Scurvy.

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Abstract
The injn. of insulin or adrenal cortical extract into scorbutic guinea pigs fasted then given 2.5 g. of glucose did not influence the low glycogen levels, the impaired intestinal absorption, or the high blood sugar levels. Respiration trials run on animals fed glucose then injected with insulin before and after depletion were the same. NaCl added to the drinking water failed to improve any aspect of carbohydrate metabolism studied. Adrenaline injns. produced high blood sugar in both members of the pair; the level in the deficient animal was higher than that in the normal one. Lower glycogen levels were also found in the deficient animal, but the differences between the 2 groups were of no significance. When CL-alanine was given to normal and deficient animals, less glycogen was formed than after feeding glucose. The deficient animal showed very little ability to convert this compound to glycogen.