Cefotiam concentrations in bile and in the wall of the gallbladder in patients with biliary disease

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Abstract
The biliary elimination of cefotiam, a new semi-synthetic cephalosporin, was investigated in patients with biliary disease. In patients with cholelithiasis, the mean concentrations in gallbladder bile and in the wall of gallbladder were l7·4 mg/l (±9·7 S.E.M.) and 31·8 mg/l (±7·86 S.E.M.), respectively, 30 min after intravenous injection of 1 g of cefotiam. The concentrations in hepatic bile measured in three patients with normal liver function were 1177, 149 and 1115 mg/l. In patients with obstructive jaundice who had percutaneous transhepatic bile drainage, the mean concentration in hepatic bile one hour after injection was 19· mg/l (±9·3 S.E.M.) which decreased and at 6 h was 5·9 mg/l (±5·8 S.E.M.). These patients had some liver dysfunction. Cefotiam, is excreted in bile in concentrations greater than the minimum inhibitory concentrations for Gram-negative organisms which are commonly responsible for biliary infection and this was confirmed in patients with obstructive jaundice who had abnormal liver function.

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