Newcastle Disease Virus Pathogenesis in the Respiratory Tract of Local or Systemic Immunized Chickens

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Abstract
Establishment of selective immunity, local or systemic, made it possible to evaluate the pathogenesis of Newcastle disease virus (NDV) in the respiratory tract of chickens that were previously immunized with .beta.-propiolactone-inactivated antigen. NDV was inoculated intranasally [i.n.] or i.m. to chickens in different states of immunity (local or systemic). Humoral antibodies protected chickens against i.n. and i.m. infection. Local antibodies conferred immunity only against i.n. challenge. The respiratory tract supported multiplication of the virus, producing a self-limited subclinical infection. Replication of the virus in this system was negligible, playing only a minor role in the pathogenesis of the disease.

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