Recovery of Pituitary Thyrotropic Function after Withdrawal of Prolonged Thyroid-Suppression Therapy
- 2 October 1975
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 293 (14) , 681-684
- https://doi.org/10.1056/nejm197510022931402
Abstract
The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid 131I uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, 131I uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable. After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal. Decreased thyrotropin reserve persisted for two to five weeks.Keywords
This publication has 10 references indexed in Scilit:
- Hyperresponse to Thyrotropin-Releasing Hormone Accompanying Small Decreases in Serum Thyroid Hormone ConcentrationsJournal of Clinical Investigation, 1974
- ANOMALOUS PLASMA TSH LEVELS IN PATIENTS DEVELOPING HYPOTHYROIDISM IN THE EARLY MONTHS AFTER131l THERAPY FOR THYROTOXICOSISJournal of Clinical Endocrinology & Metabolism, 1974
- Transient Lack of Thyrotropin (TSH) Response to Thyrotropin-Releasing Hormone (TRH) in Treated Hyperthyroid Patients with Normal or Low Serum Thyroxine (T4) and Triiodothyronine (T3)1Journal of Clinical Endocrinology & Metabolism, 1974
- Rapid simultaneous radioimmunoassay for triiodothyronine and thyroxine in unextracted serumBiochemical and Biophysical Research Communications, 1972
- Evaluation of a Simplified Technique for the Specific Measurement of Serum Thyroxine ConcentrationJournal of Clinical Endocrinology & Metabolism, 1971
- Triiodothyronine Withdrawal Test—A Test of Thyroid-Pituitary AdequacyJournal of Clinical Endocrinology & Metabolism, 1971
- Natural History of Pituitary-Adrenal Recovery Following Long-Term Suppression with Corticosteroids1Journal of Clinical Endocrinology & Metabolism, 1965
- THE EFFECT OF PROLONGED ADMINISTRATION OF THYROIDAnnals of Internal Medicine, 1951
- The Effect on Endogenous Thyroid Activity of Feeding Desiccated Thyroid to Normal Human SubjectsNew England Journal of Medicine, 1951
- SERUM IODINE OF EUTHYROID SUBJECTS TREATED WITH DESICCATED THYROID 12Journal of Clinical Investigation, 1945