STUDIES ON THE FLAVOR AVERSIONS INDUCED BY TRIALKYLTIN COMPOUNDS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 4  (2) , 225-230
Abstract
Experiments were undertaken to determine the suitability of a flavor-aversion-conditioning paradigm for detecting the effects of trimethyltin and triethyltin in rats. Both organotins produced flavor aversions whose magnitude depended jointly on the dosage administered and the number of flavor-organotin pairings. Estimated ED50 (for triethyltin, 1.8 mg/kg; for trimethyltin, 3.1 mg/kg) were smaller than the dosages reported to affect other classes of behavior but represented a substantial percentage (25-45%) of the respective published LD50 values. Flavor-aversion conditioning may represent a valuable tool for studying the effects of organic and inorganic heavy metals.