SECRETION OF GASTRIC MUCIN IN RESPONSE TO SHAM-FEEDING AND HISTAMINE STIMULATION

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Abstract
Expts. performed on dogs with gastric fistula and esophagotomy demonstrated conclusively that sham-feeding causes a pronounced increase in the output of "dissolved mucin" as effectively as it does that of acid and pepsin. An analysis of the curves for concn. and output of mucin, pepsin and acid shows the response of each to be independent, an indication that the respective sets of secretory cells respond in a selective manner to sham-feeding. Similar effects were obtained also with "conditioned stimuli" related to the act of sham-feeding. The stimulatory effect of sham-feeding was shown to be a primary one, independent of changes in gastric motility, and not due to the local action of the acid of the gastric juice. Expts. with histamine on atropinized, unanesthetized dogs and in sacrifice expts. under Na pentobarbital anesthesia showed that the parietal cells alone are stimulated by this substance. The output of mucin remained constant at the level of the resting stomach secretion and with larger doses even appears to be depressed.

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