Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 5 (6) , 655-680
- https://doi.org/10.1007/bf01059689
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearanceJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Application of Salivary Concentration Data to Pharmacokinetic Studies with AntipyrineJournal of Pharmaceutical Sciences, 1977
- Effects of route of administration and blood flow on hepatic drug elimination.1975
- Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metaboliteClinical Pharmacology & Therapeutics, 1975
- Statistical estimations in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Determination of Lidocaine in Blood and TissuesAnesthesiology, 1973
- Clearance concepts in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1973
- Pharmacokinetic Aspects of Intravenous Regional AnesthesiaAnesthesiology, 1971
- Binding of Anilide-type Local Anesthetics in Human PlasmaAnesthesiology, 1970
- Preliminary Model for Methotrexate PharmacokineticsJournal of Pharmaceutical Sciences, 1970