MIGRATION INHIBITION AND HOMOGRAFT REJECTION IN RATS
- 1 January 1972
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 13 (1) , 5-8
- https://doi.org/10.1097/00007890-197201000-00002
Abstract
SUMMARY The relationship of cell-mediated immunity to transplantation antigens and clinical graft rejection was studied in inbred Wistar rats using an in vitro capillary tube migration- inhibition technique. Spleen cells from animals sensitised by grafting were inhibited by donor strain (AGUS)-derived antigens but not by recipient strain (Wistar)- derived antigens. Inhibition became significant 24-48 hr before the onset of clinical graft rejection. In a comparison of the response of skin-grafted animals to a small number of heart-transplanted animals, no difference was seen in the onset of sensitisation.Keywords
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